Laser versus topical estrogen for treatment of genitourinary syndrome. What does the research say?

Clinical research shows vaginal laser therapy may offer symptom relief comparable to topical estrogen for genitourinary syndrome of menopause, making it a hormone-free option for women who cannot or prefer not to use estrogen.

Anna Rue
Anna Rue

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Laser Versus Topical Estrogen for Genitourinary Syndrome of Menopause

Research comparing vaginal laser therapy and topical estrogen shows both approaches may improve symptoms of genitourinary syndrome of menopause.

Genitourinary syndrome of menopause is a common condition affecting many women as estrogen levels decline. Symptoms may include vaginal dryness, irritation, discomfort, and urinary changes that impact daily comfort and quality of life.

For many years, topical estrogen cream has been a standard treatment with consistent clinical results. However, not all women tolerate estrogen well, and some have medical contraindications or prefer to avoid hormone-based therapies altogether.

What Does the Research Say?

According to research published by The North American Menopause Society, vaginal laser therapy has demonstrated results comparable to estrogen therapy for the treatment of genitourinary syndrome of menopause.

In a clinical study, 30 women received vaginal laser treatment while 32 women were treated with topical estrogen. At six months follow-up, 85% of women in the laser treatment group reported significant improvement, compared to 70% in the estrogen therapy group.

Overall satisfaction rates ranged between 70–80% at six months post-treatment, suggesting that laser therapy may be an effective alternative for selected patients.

Laser Therapy as a Hormone-Free Option

Vaginal laser therapy works by stimulating collagen production and improving tissue quality without the use of hormones. This makes it an appealing option for women who cannot use estrogen or who prefer a non-hormonal approach.

While laser treatment is generally well tolerated, it is considered an elective procedure and is typically not covered by insurance. Ongoing and future studies may further define its role and accessibility.

The VeLVET Trial

A randomized clinical trial titled The VeLVET Trial compared vaginal laser therapy directly to vaginal estrogen therapy in women with genitourinary syndrome of menopause. Results from this study support laser therapy as a viable treatment option for symptom relief in appropriately selected patients.

Choosing the Right Treatment

Treatment decisions should be individualized based on symptoms, medical history, and personal preferences. A consultation with a qualified provider can help determine whether topical estrogen, laser therapy, or another approach is most appropriate.

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